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But why work for us?

• You will work from modern, state-of-the-art laboratories and solve challenging problems for our clients.
• Our global clients range from big pharma and biotechs to academic and charitable organisations. Teamwork and communication are as important as the science we do – how we interact and communicate with our clients is part of our success.
• We foster a culture of collective responsibility and communal working. If you’re challenged by a problem, your project team, department and the company will support you to find a solution.
• We want you to have a long and rewarding career at Sygnature. We can offer a challenging, stimulating and fulfilling role in a sociable team that’s passionate about drug discovery. It’s an extremely motivating and humbling experience to discover a lifesaving drug.

The Opportunity

• To plan and conduct metabolite identification studies using samples obtained cross species from both in vitro and in vivo DMPK studies, ensuring that that level of detail provided is fit for purpose and able to meet agreed study objectives.
• Provide Met ID subject matter expertise to support Sygnature Discovery project teams and/or clients, to plan appropriate studies and/or provide interpretation of the results obtained.
• To be involved in the scheduling of Met ID studies within the team.
• To train, mentor and coach less experienced team members in the use of qualitative, semi-quantitative and quantitative LC-MS analysis for the purposes of Met ID.
• In support of method development aspects of studies, develop chromatographic methods that maximise the separation of parent and metabolites as required using both MS and UV detection methodologies for a wide range of chemical entities.
• Trouble-shooting bioanalytical measurements supporting in vitro and in vivo DMPK assays.
• Support day-to-day running of the laboratory, ensuring efficient operation of the LC-MS/MS systems including troubleshooting problems, preventative maintenance and system performance checks.
• Build strong, effective working relationships with the internal team, projects and clients.

Key requirements

• Strategic awareness and understanding and application of bioanalytical support in drug discovery.
• Significant experience in the cross species structural elucidation of drug metabolites from both in vitro and in vivo DMPK studies.
• Expert understanding of the capabilities and use of metabolite prediction software and how this can be successfully utilised in the Met ID process.
• Experienced and capable metabolism expert able to take the results of Met ID studies to construct putative metabolism pathways.
• Significant/extensive experience primarily in the use of high resolution mass spectrometers for structural elucidation but also with triple quadrupoles.
• Experienced at preventative maintenance and troubleshooting problems.
• Experienced in developing suitable chromatographic methods for metabolite identification over a wide range of chemistries using UHPLC.
• Expertise in bioanalytical method development supporting in vitro and in vivo DMPK assays.
• Good written and verbal communication skills with keen attention to detail.
• Flexible approach to work, enjoys the dynamic nature of a drug discovery environment dealing with changing priorities and deadlines.
• BSc., MSc. and/or PhD. in Chemistry, Biochemistry or related disciplines.