Purification Scientist Stevenage, England
Job description
About PerkinElmer
PerkinElmer has been named a Top 10 company on Newsweek’s UK The Most Loved Workplaces®. This recognition shows our commitment to our employees and our aspiration to create a culture and place of work where everyone feels valued.
Imagine a world where you could detect health issues sooner to treat them more effectively. Where food and water are always safe, even in remote corners of the earth. And where scientific and medical research are enhanced to solve the greatest challenges of our times. At PerkinElmer, we imagine this world every day. Then, we innovate and collaborate to make it happen everywhere.
If you are seeking a meaningful, impactful, and stimulating career, look no further.
Job Summary
We are looking for a highly motivated candidate for the role of Purification Scientist to join a new automated purification team within the GSK Medicinal Design Discovery Analytical group.
A successful candidate will be responsible for delivering and isolating high purity samples as part of the Centralized Achiral Purification Service (CAPS).
In this position, the candidate will work within a global matrix, in a collaborative, fast-paced, team environment supporting colleagues from discovery medicinal chemistry.
Job Responsibilities:
Operational
Deliver a flow process, involving varied instrumentation platforms, to enable the isolation of compounds of interest from crude mixtures.
Utilise relevant analytical instrumentation for separations method development; primarily analytical UPLC-MS.
Operate mass-directed automated purification (MDAP) HPLC platforms to purify complex, crude sample mixtures.
Identify desired chromatographic fractions and consolidate for isolation using liquid handling robots.
Removal of chromatographic purification solvents by lyophilisation and generation of post-purification analysis samples for multiple techniques, such as UPLC-MS and NMR.
Use liquid handling technology and other appropriate instrumentation (including nitrogen dry-down units and lyophilisation units) to dispense purified compounds for ongoing screening.
Oversee the collection of appropriate analytical data to characterise and register final drug candidate molecules prior to organising submission for screening.
Document purification conditions and method development used to isolate compounds and provide this information to the originating chemist.
Maintain instrumentation as appropriate and escalate any identified instrumentation or hardware issues that cannot be resolved locally to next level support, as determined by client.
Support CAPS scientists with evaluations of new chromatographic systems and related processes as appropriate.
Operate and maintain laboratory equipment in accordance with appropriate internal maintenance SOPs and work instructions.
Collect service metrics where applicable.
Follow all safety protocols and operating requirements as defined by local management and client policy.
Liaise with colleagues to determine the appropriate consumable provisions required to support ongoing CAPS progression.
Perform routine lab maintenance & organisation.
Support process improvement projects related to service deliverables as capacity allows and as approved by the PerkinElmer team manager.
Qualifications/Personal Qualities
We are looking for professionals with these required skills to achieve our goals:
Bachelor’s degree or 2+ years of experience in chemistry, analytical chemistry or a similar scientific discipline.
Demonstrated working familiarity with different analytical and preparative techniques.
Strong desire to learn with multifunctional learning agility.
Self-motivated.
Outstanding verbal and written communication.
Basic preparative instrumentation knowledge including simple maintenance and repair.
Ability to multitask across purification and analysis.
Ability to manage the workflow within the group.
Experience with analytical method development and preparative chromatography in small molecule pharmaceuticals.
Ability to analyse chromatographic data and make decisions for follow up experiments
Awareness of Waters analytical and preparative chromatography systems.
Physical/Mental Demands
The overall physical exertion of this position may require:
Sit or stand 4-5 hours in laboratory areas.
Reach above/below the shoulder, bend at the knees and waist.
Office work activities, including computer-based activities
Work around moving laboratory equipment and machinery.
Use of personal protective equipment in laboratory.
Work with biohazards such as hazardous compounds and chemical in compliance with local safety rules and regulations.
Working Environment
Must be able to work in a laboratory, controlled environment requiring personal protective equipment.
Job pace may be fast and job completion demands may be high.
Employee will be required to manage hazardous wastes in compliance with local company procedures & UK hazardous waste regulations. Duties may include: identifying, handling, generating, accumulating, storing, labelling and appropriate disposal.
