Molecular and Cell Biology Senior Research Scientist Oxford, England

Vertex Pharmaceuticals

Full Time Oxford, England 47865 - 60229 GBP ANNUAL Today

Job description

Job Description

This is a high impact position within the Dept of Integrative Biology, which is dedicated to the discovery of novel and effective medicines using innovative approaches. This state-of-the-art department comprises several complementary functions focused on identifying new targets and progressing a small molecule portfolio. The Molecular Cell and Biology Senior Research Scientist works with independence and is adept at conceptually outlining studies to design and execute focused research projects or a series of complex experimental procedures. These may include studying disease biology in patient-relevant cellular models using appropriate readouts of the disease or target mechanisms under investigation. Completes work in a resourceful, self-sufﬁcient manner and is able to design alternative approaches to achieve desired outcomes. Keeps current on the scientiﬁc literature relevant to scientiﬁc methodology or ﬁeld(s) of technical expertise. This level captures the Research organization’s senior level for staff with a research doctoral degree (PhD) and postdoctoral experience. With an emphasis on tackling causal biology in order to make transformative therapies for patients, this position is well-placed to generate and analyse novel cellular, protein, and molecular biology data for target discovery in many exciting new therapeutic areas.

Key responsibilities

Independently and in collaboration, build a highly informative plan of work which provides rapid stop/go decisions on novel hypotheses and targets.
Designs and conducts elaborate, conceptually connected, multi-component experiments which use a variety of techniques acquired from molecular and cellular biology, which could include:
- Mammalian cell culture, manipulation, and maintenance.
- Generation and use of cell lines derived from ex vivo material (including primary organoids and explants) and differentiated stem cells. iPSC model development experience is a plus
- Cellular assays, in multiple assay plate formats including 96 well plates, capturing the effects of disease-associated variation on relevant phenotypes and molecular signatures.
- Gene expression approaches including qPCR, NextGen sequencing, FACS, ICC, and Western blot.
Collates and interprets data systematically and synthesizes results into a cohesive body of conclusions or recommendations to guide Project decisions and new research activities.
Scours relevant scientiﬁc literature and routinely incorporates new insights into research activities.
Explores the feasibility of applying new scientiﬁc principles/concepts or implements and validates new experimental approaches and technologies to achieve project goals.
Independently prepares presentations and presents experimental conclusions at internal Group/Department or Project Team research meetings.
Embrace and embody an entrepreneurial spirit to find innovative solutions to complex biological problems.
Performs other duties as assigned.

Knowledge and Skills:

Ability to design and execute complex experiments, including mechanistic investigation in disease-relevant contexts.
A broad working knowledge of fundamental biology principles. Demonstrates astute understanding of own discipline and the relevant literature.
Maintains a high level of knowledge related to current developments in the scientiﬁc Project ﬁeld.
Displays proven productivity and experimental creativity, and effective dissemination of ideas.
Demonstrates awareness of other Project-related disciplines and an understanding of general concepts and some experimental detail within those areas.
Experience handling and designing experiments using human tissue a requirement.
Wide-field and confocal microscopy and image analysis experience is a major plus.
Immunology background is a plus.

Education and Experience:

Ph.D. (or equivalent degree) in molecular biology, cell biology, biochemistry, or related disciplines.

Proven track record for solving complex scientific problems and delivering high quality results, as demonstrated through e.g. an excellent publication history, supported by evidence of major individual contributions.