Senior Scientist (B cell), Biologics Engineering, Oncology R&D - 1 year contract Cambridge, East of England
Job description
Available Job Today This is a 1 year fixed term contract based on-site in Cambridge.
Do you have expertise in therapeutic antibody discovery using groundbreaking B-cell technologies? Would you like to apply your expertise to impact the next generation biotherapeutics portfolio in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!
About AstraZeneca
At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.
Site description
Granta Park, Cambridge (UK), one of over 400 sites here at AstraZeneca, providing an environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you…Cambridge is one of the most bioscience hotspots in the world and plays a central role in our mission to deliver life-changing medicines to patients. Granta Park has a gym, nursery and central restaurant/coffee place as part of the science park facilities that are accessible to our staff. We also have our own bistro and deli in the AZ buildings. There are regular lunch & learn events including running clubs and after work socials on the last Friday of every month. This is our biggest and most spacious lab site with easy access from all major routes and ample car parking available - come and join us! Please be aware that towards the end of 2022 you will be required to move the our new Cambridge Biomedical Centre.
Business area
In the Oncology Business Unit we relentlessly follow the science, challenging the status quo to deliver more effective treatments to patients in need. Our dedication means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease. Fast-paced, it takes agility and responsiveness to stay committed in our pursuit of excellence. We work with focus to seek the unanswered questions – innovating, questioning accepted norms, quick decision-making and doing things differently.
What you'll do
You will form part of a multi-functional team responsible for the isolation of therapeutic antibodies and tool reagents using in vivo antibody discovery technologies.
As a Senior Scientist you will generate and QC bespoke reagents (proteins, conjugates, cell lines, genetic expression constructs (e.g. plasmid DNA)) for in vivo antibody generation projects.
You will perform the in vivo antibody discovery process including: antigen specific B-cell isolation by flow cytometry or hybridoma generation, automated colony picking, primary characterization of in vivo-derived antibodies using both biochemical and cell-based screens, antibody gene isolation and cloning, sequence analysis of antibody clones, hybridoma propagation, and antibody purification, in order to support projects in the identification of lead antibodies.
In addition, you will contribute to projects aimed at improving process efficiency and investigate new methodologies, techniques and/or equipment that may be beneficial for the in vivo antibody discovery process and/or add value to the team’s functional output.
Responsible for day-to-day lab management and represent the lab at site lab rep meetings.
Essential for the role
PhD; or BSc/MSc with extensive laboratory experience in molecular biology /Cell Biology/Biochemistry
Demonstrated laboratory skills and experience in the following: Molecular biology (e.g. PCR, cloning, sequence analysis) and mammalian cell culture
Protein expression, purification and QC analytical techniques
Performing routine biochemical assays (e.g. ELISA, HRTF, western blotting, etc.)
Desirable for the role
Experience of protein conjugation
Experience with hybridoma generation
Experience working with primary cells
Experience of performing cell-based assays
Practical experience of laboratory automation and LIMS systems
Practical experience of protein engineering
Experience within pharmaceutical/biotechnology industry
Experience of recombinant cell line generation
So, what’s next?
Are you already envisioning yourself joining the team? Good, because we can’t wait to hear from you.
Are you ready to bring fresh thinking to the table? Brilliant! We have one seat available, and we hope it’s yours.
Competitive salary package and benefits
Close Date: 19/04/2023
Where can I find out more?
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