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Sosei Heptares is an international biopharmaceutical company with a mission to make a significant contribution to improving the quality of life and health of people around the world. To achieve this, we will discover, design, and develop the most innovative and effective medicines for patients worldwide, through our world-leading patent-protected technology and platform.

Our core focus is on the discovery and early development of new medicines originating from our proprietary G Protein-Coupled Receptor (GPCR) targeted StaR® technology and Structure Based Drug Design (SBDD) platform capabilities. Today, we are advancing a broad and deep pipeline of novel medicines across multiple therapeutic areas, including neurology, immunology, gastroenterology, and inflammation diseases.

We have established partnerships with some of the world’s leading pharmaceutical companies and multiple emerging technology companies, including AbbVie, AstraZeneca, Biohaven, Genentech (Roche), GSK, Neurocrine Biosciences, Novartis, Pfizer, Takeda and Verily.

Sosei Heptares is headquartered in Tokyo, Japan with corporate and R&D facilities in London and Cambridge, UK. We have approximately 170 employees based at our state-of-the-art R&D research centre at Granta Park, Cambridge. The size of our company ensures optimum agility and transparent linkage between all activities from early discovery through to clinical development.

For more information, please visit https://soseiheptares.com/. LinkedIn: @soseiheptaresco | Twitter: @soseiheptaresco | YouTube: @soseiheptaresco

Position:

We are currently seeking an experienced molecular biologist to join the Protein Engineering group working on GPCR structure determination to enable drug discovery efforts.

The successful candidate will be expected to work independently, and the role will include the following responsibilities:

• Cloning of plasmid constructs for expression;
• Expression of GPCRs in insect, yeast and human cells;
• Characterization of GPCRs in membranes and in detergent-solubilised form using ligand binding assays;
• Establishing and optimising thermal stability assays;
• Mutant library generation and directed evolution of proteins;
• Screening for stabilising mutations using our proprietary platform to create StaR® proteins;
• Construct engineering to optimise expression;
• Purification and biochemical characterisation of GPCRs using a range of techniques such as size exclusion chromatography;
• Development of novel technologies for stabilising and determining the structures of GPCRs
• Optimising expression of other membrane proteins (e.g., ion channels and transporters)
• Careful documentation of experimental work; and,
• Work closely with molecular biologists, protein expression scientists, biophysicists, structural biologists, and pharmacologists to help advance the project.
• This is an exceptional opportunity to participate in pioneering science with an Industry-leading Drug Discovery company.

Requirements:

• PhD in a relevant area of biology
• Ability to work flexibly within a team, whilst being highly self-motivated and able to work independently;
• Analytical thinking and good problem-solving skills;
• Excellent organisational and time-management skills, including the ability to work to strict deadlines;
• Fluency in oral and written English is essential; and
• Relevant lab experience would be preferred including:
• Experience in a variety of molecular biology cloning techniques;
• Proficient in cell culture techniques for the expression of membrane proteins in mammalian, insect and yeast cells;
• Experience in membrane protein purification;
• Experience of assay development and optimisation;
• Experience in flow cytometry;
• Experience in GPCR in vitro pharmacology and GPCR biochemical assays would be desirable.

Other information:

What’s in it for you?

• 
  State-of-the-art R&D centre located in the heart of the Cambridge science cluster

• Competitive compensation package including discretionary cash bonuses

• Eligible for grants of Restricted Stock Units in Sosei Group Corporation

• 25 days annual leave in addition to public holidays

• Employer contribution to pension

• Private Medical Insurance and a cash plan for dental and optical reimbursement

• Health and wellbeing benefits including a subsidised individual gym membership

• Income protection to cover long term absences due to ill health

• Group Death in Service equal to 4x basic annual salary



Why Sosei Heptares?

At Sosei Heptares, we are dedicated to the pursuit of scientific innovation. Our mission is to make a significant contribution to improving the quality of life and health of people around the world. To achieve this, we will discover, design, and develop the most innovative and effective medicines for patients worldwide, through our world-leading patent-protected technology and platform

Working at Sosei Heptares

The Sosei Heptares R&D centre is a modern, state-of-the-art centre located within easy shuttle reach of Cambridge and Whittlesford Parkway train stations. We offer a collaborative, diverse and inclusive working environment that considers your individual needs and believes in maintaining a sustainable work-life balance. You will be welcomed by a team of colleagues with decades of accumulated experience in their areas of expertise, happy to help you develop your own skills in a highly collaborative environment and who are keen to provide guidance and support in your personal and career development plans.

Our Vision and Values

To become one of Japan’s science and technology-led biopharmaceutical drug discovery champions. To achieve this, we will leverage our global know-how and operating agility to deliver a sustainable pipeline of first or best-in-class therapeutics, ensuring our place amongst the next generation of leading innovators.

We are guided by three fundamental values.

• 
  Limitless Compassion

• Unswerving passion

• Continuous self-innovation

These unchanging set of core values that serves as a guide across all our activities

Join Us!

Other information

The successful candidate will be employed by Heptares Therapeutics Ltd, a UK wholly owned subsidiary of Sosei Group Corporation.

Sosei Heptares is committed to building a diverse and ambitious workforce, and to promoting equal opportunities in employment. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment: we do not discriminate based on age, disability, gender reassignment, marriage and civil partnership, pregnancy and maternity, race, religion or belief, sex, sexual orientation, or any other classification prescribed by law.

Applications should include a CV and covering letter, providing a short description of the background of your interest in the role, and apply via our on-line jobs’ portal: https://bit.ly/3v7NJh0 in pdf format, quoting reference number 2023-Protein Engineering - RS. The closing date for applications is 7th July 2023.

C.K. Group are our partnered agency on this role.