research scientist Tarrytown, NY
Job description
JOB DESCRIPTION
The Viral Delivery Technologies group is seeking an independent and highly motivated Senior Scientist to aid in developing novel viral vectors. We see this position as critical for conducting research activities around the design, characterization, and validation of novel Adeno-associated virus vectors in vitro and in vivo. We hope you are passionate about working to expand our antibody-retargeted viral vector platform for gene therapy applications by developing the efficacy and tissue specificity of vectors.
As a Senior Scientist within the Viral Delivery Technologies group, a typical day might include the following:
Designing, performing, analyzing, and troubleshooting in vitro experiments to characterize and validate new antibody target receptors and viral vector constructs.
Producing, purifying, and titrating AAV vectors.
Running cell-based assays to characterize the infectivity efficacy and specificity of novel AAV vectors.
Performing cloning, Western blotting, DNA/RNA extractions, PCR, RT-PCR, qPCR, etc.) and biochemical/immunological assays (ELISA, flow cytometry).
Working closely with therapeutic groups to identify targets, design in vivo experiments, evaluate vector bio-distribution, and develop therapeutic applications of retargeted viral vectors.
Evaluating candidate antibodies to target tissues of cell types of interest for viral gene delivery.
Coordinating with CROs to evaluate candidate viral vectors in non-human primate models.
Working collaboratively with other department team members and with collaborators in various therapeutic focus areas across research and discovery.
Participating in team meetings and preparation of presentations for meetings.
This role might be for you if:
You are able to work methodically and independently with minimal direction, in a highly collaborative and fast-paced environment.
You have relevant experience in molecular biology techniques, mammalian cell culture, manipulation and purification of viruses or proteins, development and use of cell-based assays for detection of reporter proteins, and use of antibodies for various applications.
You have previous experience with AAV production and manipulation, in vivo delivery, and in vivo characterization of viral vectors, as well as familiarity with key antibody properties will constitute distinct advantages.
To be considered for this opportunity, you must have a minimum of a Master’s degree in molecular biology, biochemistry, biotechnology, virology, or a related field. Candidates with a Ph.D. will also be considered. Excellent communication skills and a strong work ethic are crucial.
Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.
The salary ranges provided are shown in accordance with U.S. law and apply to U.S. based positions, where the hired candidate will be located in the U.S. If you are outside the U.S, please speak with your recruiter about salaries and benefits in your location.
Salary Range (annually)
