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This is a rare and exciting opportunity for an inspiring, experienced and forward-thinking Medicinal Chemistry Leader to provide effective medicinal chemistry expertise and leadership of an integrated small molecule drug discovery program. The Associate Principal Scientist – Medicinal Chemistry role will provide medicinal chemistry project support, logistics and leadership for client projects.

At Pharmaron we offer:

• Vibrant and dynamic employment – we are a highly specialised, growth company operating in a critical sector of the economy – our future is strong and exciting!
• Opportunities to develop your skills and yourself – our rapid growth brings greater opportunities for you to learn and grow faster!
• A great team where we all support each other – enjoy your work – after all you spend about a third of your time here!

Requirements:

• 
  PhD degree in the area of Organic / Medicinal Chemistry or equivalent industrial experience
• Demonstrate expertise in the core medicinal chemistry skills required to support drug discovery projects, with limited guidance from a scientific supervisor / Line Manager. Such skills include but are not limited to, the development of structure-activity relationships, analysis of data and design of compounds to probe appropriate hypotheses in the development of molecules towards clinical candidates.
• Multi-year experience working in medicinal chemistry gained in academia, Pharma/Biotech and/or CROs.
• Technically expert and able to work autonomously within the area of expertise with a strong project delivery focus.
• Experience in both hit-to-lead and lead optimisation phases of compound development would be advantageous
• Excellent knowledge of medicinal and synthetic organic chemistry, and working knowledge of DMPK/ADME assays and parameters.
• Organizes and directs own and supervises team efforts, where appropriate.
• Demonstrable knowledge and/or experience of the drug discovery process for small molecules, from hit identification through to clinical candidate selection.
• Able to critically review relevant scientific literature and assess patent literature, to ensure compounds are novel, and have freedom to operate, and relevant flowcharts are in place.
• Familiarity with the use of industry-standard IT tools, data analysis and chemistry software packages.
• Adapt quickly to new priorities, emerging data and challenges. Communicates clearly and influences effectively. Passion for learning new applications, technologies and skills, contributing to innovation and problem-solving.
• Demonstrates constant client orientation and focus, developing effective working relationships with clients and customers to enable efficient project progression, and responding in a timely manner to all enquiries.
• Anticipates and handles critical situations, taking into account all positions and viewpoints through open communication and being receptive to different or innovative viewpoints.
• Seeks opportunities to provide a supportive environment by helping other team members, the department and the organization.

Key roles and responsibilities:

• Design and coordinate core experiments with laboratory teams, interpret results and plan additional experiments in a timely manner to solve assigned problems of high complexity.
• Use expertise to troubleshoot synthetic issues in collaboration with UK or China-based synthetic chemists.
• When required by the project, design and execute synthetic chemistry experiments, interpret results, and plan additional experiments in a timely manner to solve problems of high complexity leading to the preparation of the desired target molecules.
• Actively participate in the identification and implementation of new technologies or methodologies, as appropriate within functional areas, maintaining continuous improvement in function and teamwork processes.
• Effectively communicate, coordinate and collaborate with clients and cross-functional project groups to ensure that scientific work is appropriately documented via presentations both internally and externally to the client.

Our Company: “We are a dynamic, fast-growing company, with an enviable reputation for leading edge science, offering contract research services to some of the world’s leading pharmaceutical companies, solving what were believed to be unsolvable scientific challenges”.

We believe in our ability to relentlessly push forward the boundaries of scientific excellence, delivering solutions for our clients, always operating ethically and with integrity. We take pride in our professionalism and commitment to always deliver our very best work.

Pharmaron acquired the Hoddesdon campus, consisting of several purpose built scientific and administrative buildings together with a purpose built conference area in February 2017. The research building has more than 5,000m2 of premier R&D space and houses an established Process Chemistry, Analytical Chemistry and Drug Discovery teams. In addition, a Formulation Development team was also recently established. The Hoddesdon site has state-of-the-art Good Manufacturing Practice (GMP) standard facilities for the development of Active Pharmaceutical Ingredients (API), Formulation Development (FD) and Process Chemistry (PC).

• 
  We offer a competitive salary and a progressive and comprehensive suite of employee benefits.
• We offer state of the art working environment on site.
• We offer the opportunity for growth and development and will support funding for relevant training and development programmes.

Why Should You Apply?

• This is an opportunity for you as an Associate Principal Scientist – Medicinal Chemistry professional to make a real impact in a highly scientific and regulated environment, demonstrate leadership, ambition and the desire to grow with the department.
• Build and shape your career in an environment that sets and commits to the highest standards.
• To be part of a team who support each other, embrace and solve technical challenges and put excellence at the heart of all that we do.

Pharmaron is a premier R&D service company supporting the life sciences industry. Founded in 2004, Pharmaron has invested in its people and facilities having established diverse drug R&D service capabilities, ranging from synthetic, medicinal, and analytical chemistry, biology, DMPK, pharmacology, drug safety assessment, radiochemistry and isotopically labelled metabolism, chemical & pharmaceutical development to clinical development. With operations in China, US and UK staffed by over 19,000 employees, Pharmaron has an excellent track record in the delivery of R&D solutions to its partners in North America, Europe, Japan, and China.