research scientist Oxford, England
Job description
The position
We are looking for a Senior Research Scientist in Genetics to implement cutting-edge human genetics insights to answer questions that will improve trial success and support human-genetics driven precision medicine for cardiometabolic disease. The position is located in Oxford or London (the London location to be confirmed).
In this role you will:
- provide human genetic support to project teams responsible for the progression of given therapies through the drug pipeline
- work closely with colleagues to identify areas where genetics can help guide decision making e.g., indication selection, adverse effects
- use genetic data with other omics - proteomics, metabolomics, transcriptomics, and epigenetics - to better understand and personalize treatment responses
- support trial data with genetics to inform decision making and identify populations that will respond best to the treatments developed by our scientists.
We welcome candidates with human genetics knowledge applied in a drug discovery or development setting to enhance our precision medicine efforts.
The Human Genetics Centre of Excellence (CoE) in Oxford is part of a collaborative endeavour where you will work alongside statistical geneticists, clinicians, and computational and laboratory scientists from across the organisation, and with external collaborators, to help get the right treatment to the right patient.
As a person, you have a good team ethic, who pay close attention to detail, enjoy a fast paced, dynamic environment where creative intellectual independence and knowledge sharing is actively encouraged. Most importantly, you must have a strong interest in applying your skills in the field of drug development.
Qualifications
The ideal candidate holds a Ph.D. in human genetics, statistical genetics, genetic epidemiology, pharmacogenomics, or other related fields.
Additionally, you:
- have a solid PhD experience with approaches for marker-trait and gene-trait association (GWAS, PheWAS, TWAS, QTL mapping, Mendelian randomization, etc). Previous experience in handling omics data (e.g., transcriptomics, proteomics) would be considered an advantage
- Have knowledge and experience of data-driven methods to characterize multimorbidity and a general understanding of the biology and pathophysiology underpinning cardiometabolic diseases
- Possess knowledge of, and experience using programming languages, for analysis of large-scale datasets, e.g., R, Python, or similar
- Have experience of communicating insights and presenting concepts to a diverse audience.
- are self-driven and work well in interdisciplinary teams.
About the Department
You will be a member of our Genetics Trials & Precision Medicine Department which is part of the Human Genetics CoE led by Vice President, Joanna Howson PhD. The focus of the CoE is to use data science and human genetics to discover and develop new drug targets and biomarkers through a range of human centric approaches e.g., high-through put genetic discovery screens; Mendelian randomization; pLoF variant screens and precision medicine approaches relevant to type 2 diabetes, chronic kidney disease, CVD, non-alcoholic steatohepatitis (NASH), obesity and rare endocrine and blood disorders.
You will be based at Novo Nordisk’s research Centre Oxford (NNRCO) in the heart of the world leading University of Oxford Medical campus. NNRCO is focused on bringing together in vitro and in silico scientists to discovery new biology and targets across the spectrum of cardiometabolic diseases. You can read more about Novo Nordisk Research Centre Oxford at: http://www.novonordisk.co.uk/about-novo-nordisk-in-uk/oxford-research-centre.html
The CoE is anchored in the newly established Digital Science & Innovation (DSI) organisation within Research & Early Development at Novo Nordisk. DSI is supporting the digital journey across all our therapy areas in R&ED. In DSI, we work in multidisciplinary teams in strong collaboration with all areas across R&ED and R&ED IT. We participate in drug development projects across the value chain, from early discovery to pre-clinical development. We engage in external collaborations to ensure access to the latest research and technology enablers, and we automate our labs and processes, and we focus on developing and retaining top talent.
Working at Novo Nordisk
At Novo Nordisk, we don’t wait for change. We drive it. We’re a dynamic company in an even more dynamic industry, and we know that what got us to where we are today is not necessarily what will make us successful in the future. We embrace the spirit of experimentation, striving for excellence without fixating on perfection. We never shy away from opportunities to develop, we seize them. From research and development, through to manufacturing, marketing, and sales – we’re all working to move the needle on patient care.
Contact
Please submit your application via the Novo Nordisk website. We are unable to accept direct CVs.
Deadline
6th August 2023
We commit to an inclusive recruitment process and equality of opportunity for all our job applicants.
At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.
