research scientist Alderley Park, England
Job description
Are you an ADME scientist with a minimum of 5 years industry experience supporting drug discovery programmes, looking for a new challenge within the drug metabolism (ADME)field? If so, then this could be the opportunity for you!
Role: Associate Principal Scientist - Drug Metabolism (ADME), Permanent
Hours: Full- time, 37.5 hours per week
Location: Alderley Park, Macclesfield, SK10 4TG.
Our Company
Cyprotex vision is to be pioneers of innovative ADME-Tox partnerships, driving the delivery of safer and more effective medicines. With state-of-the-art facilities and technical expertise, we specialise in in vitro and in silico ADME-Tox services, providing a wide range of assays tailored to our client’s needs. This includes in vitro ADME screening to support discovery projects, regulatory in vitro ADME and DDI studies to support preclinical and clinical development, specialist mechanistic in vitro human and animal toxicity models and PBPK/QSAR modelling expertise. As well as supporting clients directly, we have a strong focus on R&D.
Our Alderley Park site is set in the heart of Cheshire surrounded by a stunning 400-acre estate, open green spaces, and sweeping viewpoints, all within easy reach of Merseyside and Greater Manchester, Staffordshire, Shropshire and Derbyshire. Easy access to public transport.
As a result of year-on-year success within the company and continued business growth, exciting opportunities have arisen to join our team of 30+ drug metabolism scientists. We are responsible for delivering high-quality drug metabolism, enzyme inhibition and enzyme induction data to our clients, supporting projects from early discovery right through to clinical development. As an experienced ADME scientist, you will utilise your skills and knowledge to drive the continuous improvement of existing assays and the design and implementation of new assays to support client requirements.
The Role of Associate Principal Scientist
As an associate principal scientist, you will be working closely with other members of the team supporting study managers and business development with discussions with external partners utilising your drug metabolism and drug interaction experience to support study design and data interpretation. You will also be involved leading both commercial and R&D projects in the drug metabolism team, ensuring these are performed to a high standard and within scheduled time frames. In addition, as a visible leader in the group, utilizing excellent communication, organizational and technical skills, you will support the training and development of staff, improving the team’s knowledge and processes.
Key Responsibilities
- A senior point of contact within the group for operational and scientific support across all routine assays i.e. inhibition, induction and metabolic stability (troubleshooting, data analysis and interpretation).
- To drive assay development and validation with input into the R+D strategy of the group.
- To provide practical scientific guidance to others, collaborating across functions to meet project goals, and regularly presenting findings.
- Maintain an awareness of team’s priorities to support effective planning of group’s resources for commercial and R&D deadlines.
- Support routine high-throughput screening and bespoke assays when required.
- Responsible for managing and coordinating multiple projects/activities within the group with a results-driven approach.
- Responsible for designing assays to support bespoke studies.
- To coach, mentor and line manage other members of the team.
- Proactively take initiative to improve group processes and make efficiency gains in assays. Encourage a continuous improvement culture and manage projects to completion.
- To provide expert scientific support for the wider company for drug metabolism studies
- To keep up to date with scientific literature advances, developments, and regulatory guidelines in the area of drug metabolism science and informs the team of relevant developments.
Education, Qualifications and Experience
- MSc or BSc degree or equivalent with a minimum of 5 years experience working within an industry laboratory environment. The experience could be from within a Pharmaceutical company, Biotech or CRO.
- Direct experience in in vitro drug metabolism/and metabolism-mediated drug-drug interaction assays is essential.
- Experience in validating and routinely supporting assays using the following platforms is advantageous: liquid handling robotics (such as Tecan EVO® platform), LC-MS/MS or LC-ToFMS analysis and subsequent data analysis.
- Line management and/or direct coaching, mentoring experience is essential.
- Strong knowledge of performing and processing in vitro drug metabolism assays in-line with up-to-date regulatory guidance.
- Strong leadership capabilities, specifically the ability to coach, develop and motivate a team to continually deliver high quality data in fast-paced environment, as well as the ability to enable change and inspire a sense of purpose and direction in others.
- Able to manage multiple activities and priorities simultaneously to achieve tight deadlines.
- Possess excellent attention to detail, performing work to an exceptionally high standard, and within the company and statutory safety regulations, with good verbal and written communication skills
Job Types: Full-time, Permanent
Salary: From £42,000.00 per year
Benefits:
- Casual dress
- Company events
- Cycle to work scheme
- Employee discount
- Flexitime
- Free parking
- Gym membership
- Health & wellbeing programme
- Life insurance
- On-site parking
- Private dental insurance
- Private medical insurance
Schedule:
- Day shift
- Flexitime
- Monday to Friday
- No weekends
Supplemental pay types:
- Performance bonus
- Yearly bonus
Work Location: In person
Reference ID: JOB ID-08266
