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The post holder will be highly motivated and organised with knowledge of gene and cell therapy, process development for virus production, and experience with producer cell line development for virus manufacturing. Required technical skills include molecular biology, cell culture in different platforms, aseptic techniques and associated analytical methods such as flow cytometry, ELISA, and qPCR. They will closely collaborate with other Autolus teams, including GMP production at Stevenage and contribute to the development of processes suitable for manufacture of high-quality therapeutic products. This will include small scale vector production, purification, and analytical method development.

Key Responsibilities

• Screening and determination of best conditions for viral vectors production.
• Perform experiments to characterize and optimize critical manufacturing process parameters.
• Execute experiments leading to the development and implementation of Product and Process improvements.
• Data analysis from multiple experiments and authoring reports.
• Collaborate with team members, Team Lead/Scientist to execute, and analyse experiments to develop processes suitable for the purification of viral vectors.
• Perform analytical methods to support process development activities.
• Generating experimental write ups and reports
• Assist in technology transfer to Manufacturing group.
• Support instrument maintenance and calibration and general lab housekeeping.
• Any other duties as required following consultation with the post holder.
• The post-holder will be responsible for adhering to all health and safety guidance, provided by the Company.