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The Nagarajan lab within the Division of Molecular and Cellular Function, School of Biological Sciences wish to appoint a laboratory-based Research Associate to an exciting project exploring transcriptional mechanisms of aggressiveness in breast cancers.

During this position, the post-holder will undertake a range of activities including: identify or streamline interesting epigenetic targets and validate/elucidate their role in aggressiveness/drug resistance/metastasis using functional next generation sequencing technologies like immunoprecipitation-based proteomics, ChIP-seq, RNA-seq, ATAC-seq and chromatin conformation studies on CRISPR-Cas9 based knockout models and mice xenografts. The candidate will also establish single gene based CRISPR knockout/in models and CRISPR screens. At the end of the project, the candidate is expected to be familiar in establishing the reprogramming of enhancer regulation which makes the cancer cells to be aggressive.

Essential Skills, Knowledge and Experience:

• Hold (or expect to hold shortly) a PhD in Biology, Biochemistry, Molecular Biology or Bioinformatics with wet lab experience
• Basic/extensive knowledge in techniques of molecular biology, cancer biology or epigenetics
• A willingness to contribute practical and intellectual help and supervision of PhD students

Desirable Skills:

• Basic/extensive knowledge in techniques of transcriptional biology, ChIP-sequencing, RNA-sequencing and/or bioinformatic analyses
• Extensive experience in CRISPR-Cas9 techniques, ATAC-sequencing, single cell gene expression analysis and mass spectroscopy-based approaches.

This post is funded by the Breast cancer Now charity.

What you will get in return:

• Fantastic market leading Pension scheme
• Excellent employee health and wellbeing services including an Employee Assistance Programme
• Exceptional starting annual leave entitlement, plus bank holidays
• Additional paid closure over the Christmas period
• Local and national discounts at a range of major retailers

As an equal opportunities employer we welcome applicants from all sections of the community regardless of age, sex, gender (or gender identity), ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

Our University is positive about flexible working – you can find out more here

Hybrid working arrangements may be considered.

Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies.

Any recruitment enquiries from recruitment agencies should be directed to [email protected].

Any CV’s submitted by a recruitment agency will be considered a gift.

Enquiries about the vacancy, shortlisting and interviews:

Name: Dr. Sankari Nagarajan

Email: [email protected]

General enquiries:

Email: [email protected]

Technical support:

https://jobseekersupport.jobtrain.co.uk/support/home

This vacancy will close for applications at midnight on the closing date.

Please see the link below for the Further Particulars document which contains the person specification criteria.