Research Associate (Bioinformatician) (Huntly Lab) Cambridge, East of England, England
Job description
We are seeking an enthusiastic, dynamic and ambitious bioinformatician to join the group of Professor Brian Huntly in the Department of Haematology and Wellcome-MRC Cambridge Stem Cell Institute (https://www.stemcells.cam.ac.uk/people/pi/huntly). Our group studies the mechanisms of transcriptional and epigenetic dysregulation that drive leukaemia and lymphoma, and how these programmes are subverted from their normal role in haematopoietic stem cells and their progeny. We combine functional and genomic experiments in experimental model systems and patient samples to identify pathological mechanisms, therapeutic targets and novel therapies (e.g. Agrawal-Singh et al, Blood, 2022; Yun et al, Nature Genetics 2021; Sasca et al, Blood 2019; Gozdecka et al, Nature Genetics 2018). We are a leading multi-disciplinary lab with substantial grant funding (e.g. recently renewed £2.2m CRUK Discovery Programme Award funding this post). We are highly productive, internationally recognised and enjoy collaborations worldwide.
Your work will involve analysis of a wide range of genomic data, including ChIP-Seq, scRNA-Seq/10X multiomics, ATAC-Seq, promoter-based capture Hi-C and capture Perturb-Seq. You will work with single cell and bulk transcriptomics, 3D DNA-DNA interaction and transcriptional/epigenetic/cis-regulatory network modelling and ideally have experience of programming, scripting and statistical data analysis. Your role in the group is highly valued, working closely with lab-based researchers and other bioinformaticians to ensure the quality of our data and analysis. We have a strong tradition of putting bioinformatics at the heart of our research with bioinformaticians often being first, co-first or significant authors on our papers (e.g. Meduri et al, iScience, 2022; Horton, Madrigal-Bayonas et al, in preparation).
Cambridge is one of the best places in the world to be a biomedical scientist. The Cambridge Biomedical Campus is the largest biomedical research campus in Europe and offers unique opportunities for collaboration. Links with industry abound, with major biotech companies, including AstraZeneca, basing their operations here. Cambridge is a global centre for bioinformatics, home to institutions including the EMBL European Bioinformatics Institute and the Wellcome Sanger Institute, with which we have strong links. You will be based in the University of Cambridge's £94m flagship Jeffrey Cheah Biomedical Centre with purpose-built bioinformatics space, dedicated access to our High Perfomance Computing facility and a thriving bioinformatics community.
You will have a PhD in a relevant discipline and experience of developing or adapting computational pipelines and developing your own bioinformatic tools. Previous analysis of relevant genomic data and work in haematopoieis and/or leukaemia/cancer biology are highly desirable.
Informal enquiries to Brian Huntly at [email protected].
Fixed-term: Funds for this post are available until 28 February 2026 in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Applicants must have (or be close to obtaining) a PhD. Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £32,411) moving to Research Associate (Grade 7) upon confirmation of your PhD award. Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Please quote reference RB36230 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
