Research Associate Sheffield, England
Job description
Are you looking to learn how next generation single-molecule techniques can be applied to answer fundamental questions in neurobiology? We are seeking a Research Associate for a Wellcome Trust funded position to study the molecular mechanisms of slow axonal transport. This is a multidisciplinary project combining neuronal cell biology, advanced microscopy, biochemistry, and functional biophysical assays in vitro.
Neuronal axons can be a metre long and must be maintained for your lifetime. Axonal transport moves critical cellular machinery from where it’s made in cell bodies, out to the furthest reaches of the axon. This can be fast, up to 400 mm/day, but most material moves less than 10 mm/day. The molecular mechanisms of this slow axonal transport are poorly defined, but this is the main route to supply axons with the material they need to function. You will study the molecular details of the slow axonal transport, and how this is regulated by the availability of kinesin motors. You will use live-cell single-molecule imaging in primary neurons together with complementary functional in vitro assays. The focus of the project will be single-molecule imaging, with opportunities to apply innovative single-molecule assays and develop training in mammalian cellular and molecular biology approaches.
The project is ideally suited for scientists looking to expand their experience of multidisciplinary science. While focused on live-cell single-molecule imaging, the project supports and encourages integration of multiple single-molecule assays both in vitro and in mammalian systems; a great opportunity to build expertise across fields. We are looking for someone with a strong background and track record in molecular neurobiology, cell biology or related fields, as well as experience in microscopy. A background in single molecule methods or experience with biochemical assays is desirable but not essential.
We are looking for someone to work independently as an imaging-focused scientist, applying creative and innovative approaches to take on the research question. You will also be an excellent communicator and clearly demonstrate the ability to work effectively as part of the team. You will have the ability to handle your own workload effectively while maintaining the flexibility required for working in scientific environments. There are opportunities for regular contributions to the full range of research that our group is engaged in, which need a commitment to generating collaborative, conscientious and diverse working environments.
We strive to build a supportive environment for career development. Opportunities include support to attend and present your data at national and international meetings and to participate in further training opportunities. The role involves working closely with a number of collaborators, group members and students, and therefore requires dedication to upholding a supportive and inclusive work ethic and environment.
We’re one of the best not-for-profit organisations to work for in the UK. The University’s Total Reward Package includes a competitive salary, a generous Pension Scheme and annual leave entitlement, as well as access to a range of learning and development courses to support your personal and professional development.
We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.
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