Research Assistant (Structural biology of membrane proteins) Liverpool, England
Job description
An exciting opportunity has emerged to join the Molecular Biophysics Group to work on a BBSRC-supported collaborative project between the teams from University of Leeds and Liverpool aimed at answering fundamental questions on enzyme mechanism of quinol-dependent integral membrane nitric oxide reductases, a member of respiratory heme-copper oxidase superfamily. The project builds on our recent 2.2Å cryoEM structure of this enzyme and aims to address a number of ambitious questions through well-informed point mutations and high resolution cryoEM structures. In addition to the isolated enzyme, we also aim to obtain the first structures of CuNiR-qNOR protein-protein complexes in catalytic turnover.
We require a research assistant at Liverpool to support an experienced PDRA and the team for this project. You will be responsible for producing wild-type and mutant qNOR membrane bound proteins in sufficient quantities for functional and cryoEM studies. You would also support in producing CuNIRs and their mutants following the established protocols in our laboratories.
You should also be able to work in a team. You will have significant experience in membrane protein purification. You will be provided with a range of training opportunities including attending workshops and where appropriate conferences. You will have a degree in a relevant subject area.
This post is available from 1 October 2023 until 30 September 2026.
The University has the right to close the vacancy early if it is deemed that there have been enough applications received.
