Machine Learning Scientist

Machine Learning Scientist Cambridge, East of England, England

Astex Pharmaceuticals
Full Time Cambridge, East of England, England 59365 - 76609 GBP ANNUAL Today
Job description

Astex Pharmaceuticals is a world leader in innovative drug discovery and development. The company has successfully applied its proprietary Fragment-Based Drug Discovery platform to generate multiple new drug candidates that are progressing in clinical development. Successful collaborations have led to two launched oncology drugs (Kisqali® partnered with Novartis and Balversa® partnered with Janssen). Astex continues to grow and focuses on Oncology and Neurological Disorders.

The Opportunity

The bioinformatics team at Astex works with multi-disciplinary project teams driving new targets, preclinical and clinical research, with a focus on NGS technologies, multi-omics and functional genomics. We are looking for a candidate with a strong background in developing AI and machine-learning methods and algorithms to identify new targets and gene-disease associations and derive disease insights from multi-modal data.

Principal Responsibilities

  • Developing and implementing deep-learning approaches to analyse diverse multi-modal data (e.g. genomics, transcriptomics, imaging) to identify novel drug targets, biomarkers and drug mechanisms
  • Developing predictive models using statistical, mathematical and machine-learning methods for biomarker identification and patient stratification strategies
  • Working with bioinformaticians, statisticians and biologists to support experimental design and build data processing and analysis pipelines
  • Evaluating and assessing new machine-learning approaches developed by the research community for adoption and implementation in-house

Candidate Profile

  • PhD in mathematics, computer science, engineering, or another relevant numerical/computational discipline; alternatively, equivalent experience in relevant research (5-10 years)
  • Experience with exploration of complex data to identify key opportunities and demonstrable ability to create actionable outputs
  • Experience with advanced statistical and machine learning concepts such as Bayesian optimisation, probabilistic modelling, and neural-network design (Tensorflow/PyTorch/Keras)
  • Excellent coding skills (e.g., Python, R), experience with general numerical programming (SciPy/NumPy) and software engineering.
  • Experience in applying machine learning approaches to multi-omics data would be highly desirable
  • Experience with graph databases and formats (e.g., Neo4j) and software/ML libraries relevant to network analysis would be desirable
  • Ability to work independently and experience with line management

Why Astex

We offer excellent training and development opportunities as well as highly competitive salary and benefits package including hybrid and remote working options to promote a flexible and inclusive work environment.

At Astex we embrace diversity and equality of opportunity. We are committed to building an inclusive and diverse Company representing all backgrounds, harnessing industry-leading scientific innovation and behaviours.

Machine Learning Scientist
Astex Pharmaceuticals

www.astx.com
Pleasanton, United States
James S. J. Manuso
$25 to $50 million (USD)
51 to 200 Employees
Company - Public
Biotech & Pharmaceuticals
1991
Related Jobs

All Related Listed jobs

Gardener
London Borough of Havering Upminster, England 24804 - 26472 GBP ANNUAL Today

Supplement funeral and memorial operational activities under the supervision of trained staff. Assist members of the public, the bereaved and funeral

Care Assistant - Bank
Bupa Care Homes Croydon, England 10.45 - 11.35 GBP HOURLY Today

Assisting residents with a high standard of clinical, social and emotional care and recognising and meeting the specific needs of residents.

Driver/Handyperson
NHS Scotland Edinburgh, Scotland 23362 - 25368 GBP ANNUAL Today

The candidate will be working in a workshop environment and will be required to assist vehicle craftsperson and carry out housekeeping duties within a busy

Care Assistant
Newcross Healthcare Solutions Belfast, Northern Ireland 14.99 GBP HOURLY Today

3 months UK personal care experience from within the past 3 years. Care for the caregiver: MyHealthPlan gives you healthcare and mental health support and

Chef de Partie
Bella Italia Salford Quays Salford, North West England, England 10 - 12 GBP HOURLY Today

Salary Finance- access to savings and loans. We Care program including: 24/7 virtual GP, second medical opinion, mental health support and counselling, Get Fit