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Sosei Heptares is an international biopharmaceutical company with a mission to make a significant contribution to improving the quality of life and health of people around the world. To achieve this, we will discover, design, and develop the most innovative and effective medicines for patients worldwide, through our world-leading patent-protected technology and platform.

Our core focus is on the discovery and early development of new medicines originating from our proprietary G Protein-Coupled Receptor (GPCR) targeted StaR® technology and Structure Based Drug Design (SBDD) platform capabilities. Today, we are advancing a broad and deep pipeline of novel medicines across multiple therapeutic areas, including neurology, immunology, gastroenterology, and inflammation diseases.

We have established partnerships with some of the world’s leading pharmaceutical companies and multiple emerging technology companies, including AbbVie, AstraZeneca, Biohaven, Genentech (Roche), GSK, Neurocrine Biosciences, Novartis, Pfizer, Takeda and Verily.

Sosei Heptares is headquartered in Tokyo, Japan with corporate and R&D facilities in London and Cambridge, UK. We have approximately 170 employees based at our state-of-the-art R&D research centre at Granta Park, Cambridge. The size of our company ensures optimum agility and transparent linkage between all activities from early discovery through to clinical development.

For more information, please visit https://soseiheptares.com/. LinkedIn: @soseiheptaresco | Twitter: @soseiheptaresco | YouTube: @soseiheptaresco

Position:

This is a new position created to join an expanding Compound Management & Logistics group with a vital role in providing rapid access to compounds for experimental testing and analytical QC for Sosei Heptares drug discovery efforts in Research. As part of the Discovery Research group, we support a large portfolio of discovery programs staged from Target Identification to Lead optimisation. We work with cross-functional teams across several external collaborations and CRO’s. This a great opportunity for a lab scientist to use prior training to manage a large library of compounds using an array of automation and instrumentation. The successful candidate will have the opportunity to learn new skills in logistics, advanced robotics and collaborative working and contribute directly to drug discovery in a fast paced and challenging environment.

Prior experience is desirable but not essential for a full-time position. The Compound Management & Logistics group will consider applicants who demonstrate a strong motivation to work within drug discovery and are interested in a lab-based role to develop new skills through a focussed training initiative

Main Functions

The candidate will demonstrate a strong customer focus in a core supporting role within the Discovery group. This is a key requirement within the organisation and an employee will need to manage multiple tasks simultaneously working cross-functionally. The candidate will be expected to utilise a variety of automation, use analytical software and inventory systems to accurately process liquid and solid sample requests and maintain and record compound usage. Each team member within the group adheres to established assay protocols but are trained to navigate problems when they arise without supervision and to provide novel solutions when required.

Requirements:

The successful candidate will be expected to engage hands-on with Discovery workflows that include weighing, dissolution, compound storage/retrieval, solid & liquid dispensing, assay-ready plate generation and shipping. For a part-time position, the candidate in this lab-based role should have prior experience working within the biotech/pharmaceutical industry as the employee would be expected to already understand the drug discovery process and the supporting function of Compound Management within Drug Discovery, therefore less likely to require significant supervision/training. The employee must be driven, resourceful and able to work independently and display scientific diligence. The Compound Management & Logistics team are excellently organised in their management of data across internal and external collaborations, therefore a candidate must display an excellent attention to detail. The candidate will contribute to regular team meetings to understand new project goals and aid in weekly scheduling. Teamwork and excellent verbal and written communication skills are critical

Key Responsibilities

• Perform all Compound Management & Logistic department workflows, including manual liquid/solid transfers and preparation of solutions in plated formats using manual and automated robotics

• Generate assay-ready plates for Medium Throughput Screening & Phenotypic Target Identification campaigns using Inventory Software and electronic lab notebooks

• Create compound plates for weekly compound profiling assays

• Generate HPLC/LCMS/ADME plates for QC and work with the Analytical team to generate new assay protocols where required.

• Prepare shipping manifests and documentation for domestic and internal shipments

• Run to established protocols and develop new methods for liquid handlers, barcode readers and other automation.

• Identify new automation/software that can facilitate the Compound Management workflow

• Work closely with Informatics to implement new workflows to improve Compound Management cycle times and streamline the process

• Collaborate with scientists across multiple teams both internal and external to the organisation

• Maintain laboratory instruments to required QC in order to ensure they remain in good operation functional and perform basic troubleshooting

Other information:

What’s in it for you?

• State-of-the-art R&D centre located in the heart of the Cambridge science cluster

• Competitive compensation package including discretionary cash bonuses

• Eligible for grants of Restricted Stock Units in Sosei Group Corporation

• 25 days annual leave in addition to public holidays

• Employer contribution to pension

• Private Medical Insurance and a cash plan for dental and optical reimbursement

• Health and wellbeing benefits including a subsidised individual gym membership

• Income protection to cover long term absences due to ill health

• Group Death in Service equal to 4x basic annual salary

Why Sosei Heptares?

At Sosei Heptares, we are dedicated to the pursuit of scientific innovation. Our mission is to make a significant contribution to improving the quality of life and health of people around the world. To achieve this, we will discover, design, and develop the most innovative and effective medicines for patients worldwide, through our world-leading patent-protected technology and platform

Working at Sosei Heptares

The Sosei Heptares R&D centre is a modern, state-of-the-art centre located within easy shuttle reach of Cambridge and Whittlesford Parkway train stations. We offer a collaborative, diverse and inclusive working environment that considers your individual needs and believes in maintaining a sustainable work-life balance. You will be welcomed by a team of colleagues with decades of accumulated experience in their areas of expertise, happy to help you develop your own skills in a highly collaborative environment and who are keen to provide guidance and support in your personal and career development plans.

Our Vision and Values

To become one of Japan’s science and technology-led biopharmaceutical drug discovery champions. To achieve this, we will leverage our global know-how and operating agility to deliver a sustainable pipeline of first or best-in-class therapeutics, ensuring our place amongst the next generation of leading innovators.

We are guided by three fundamental values.

• Limitless Compassion

• Unswerving passion

• Continuous self-innovation

These unchanging set of core values that serves as a guide across all our activities

Join Us!

Other information

The successful candidate will be employed by Heptares Therapeutics Ltd, a UK wholly owned subsidiary of Sosei Group Corporation.

Sosei Heptares is committed to building a diverse and ambitious workforce, and to promoting equal opportunities in employment. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment: we do not discriminate based on age, disability, gender reassignment, marriage and civil partnership, pregnancy and maternity, race, religion or belief, sex, sexual orientation, or any other classification prescribed by law.

Applications should include a CV and covering letter, providing a short description of your background and interest in the role. Please apply through our on-line job’s portal with your application in pdf format, quoting reference number - REPLACEMENT_STRINGSci-CMLT-MolPharma. The closing date for applications is 30.04.2023.

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