Are you looking for a challenging opportunity that allows you to leverage your technical expertise to accelerate delivery in biopharmaceuticals? If so, this lab scientist in Biopharm Downstream Process Development role could be an exciting opportunity to explore. GSK is currently looking for Manufacturing Science and Technology (MSAT) Downstream Lab Scientist in Rockville, MD to join our team. The MSAT Downstream lab is responsible for all aspects of the development of purification processes for therapeutic proteins including initial process screening, optimization and characterization, validation, scale-up and tech transfer to clinical manufacturing and/or commercial manufacturing partners.

As a Lab Scientist in Downstream Process Development, you will be a member of a highly skilled team of scientists and engineers responsible for the evaluation and optimization of purification processes. You will be involved in all aspects of the development of purification processes including initial process screening, optimization, characterization, scale-up and tech transfer to clinical manufacturing and/or commercial manufacturing partners for therapeutic proteins. Your primary focus will be on the bench-scale laboratory development of purification unit operations such as column chromatography (affinity, ion exchange, HIC, mixed mode, etc.), ultrafiltration, depth filtration, nanofiltration and continuous chromatography.

Key Responsibilities:

• Learn to independently design experiments, understand the rationale for experimental design and interpreting protein purification experiments.

• Development of purification process including initial process screening, optimization, characterization, and validation.
• Process validation, scale-up and tech transfer to clinical manufacturing and/or commercial manufacturing partners.
• Perform bench/pilot-scale laboratory experiments to develop, characterize and /or validate purification unit operations such as column chromatography, filtration, ultrafiltration etc.
• Compile, analyze and communicate experimental results.
• Describe experimental results in the form of written reports and presentations.
• Work seamlessly within a team.
• Perform laboratory duties as required.
• Other duties as assigned

The role requires office work, computer work, group meetings, laboratory work and thus requires sitting, standing, and walking. It may involve working with analytical instruments and thus may involve exposure to chemical reagents that may be hazardous (corrosive, toxic, flammable, etc.)

The role may involve occasionally working outside of 0800 –1700 hours to run experiments and manufacturing support.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• BA/BS in Life Sciences, biochemistry, biochemical or biomolecular engineering or equivalent technical discipline.
• Lab experience

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Theoretical and practical understanding of protein purification and protein chemistry.
• Protein purification and process development.
• Writing, communication skills and experience using chromatography equipment such as Akta Pure. Technologies include those in the disciplines of Chemistry or other Biological Sciences
• Ability to be follow established procedures.
• Ability to be flexible, understand risk, and using analytical mindset to troubleshoot.
• Ability to continuous improvement
• Strong organizational and communication skills and attention to detail.

Why GSK?

GSK is a global biopharma company with a special purpose –to unite science, technology and talent to get ahead of disease together –so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns –as an organization where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years. Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves –feeling welcome, valued and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

#LI-GSK

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to positively impact the health of 2.5 billion people by the end of 2030.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We’re committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

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