Bioassay Development Scientist

Bioassay Development Scientist Cambridge, East of England, England

AstraZeneca
Full Time Cambridge, East of England, England 10.56 - 12.04 GBP Today
Job description

Cambridge Biomedical Campus (DISC), UK

Salary: Competitive with Excellent Employee Benefits

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company focusing on discovering, developing, and commercialising prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.

Are you a scientist who wants to apply your knowledge of cell culture and hands-on biological assay experience into a dedicated Research & Development team at AstraZeneca, Are you fuelled by the commitment to help more patients, strengthen our pipeline and grow our therapeutic areas, Are you a dynamic and highly motivated lab based scientist that can support our expanding RNA drug pipeline?

Be part of the Bioassay, Biosafety and Impurities Group accountable for developing pioneering methods to evaluate product quality by measuring biological activity and detecting, characterizing, and quantifying product variants and process-related impurities for biologics (e.g., monoclonal antibodies, RNAs, modified peptides, viruses etc). This enables product understanding, manufacturing process development, formulation, drug product development and regulatory filings to bring our drugs to the clinic and eventually onto the market.

AZ Cambridge

An exciting Life Science hotspot, Cambridge is home to one of AstraZeneca’s three strategic, global R&D Centres, alongside Gothenburg and Gaithersburg. Over 3,600 employees work from our various sites across Cambridge and our offices are internationally renowned for attracting exceptional talent.

The Discovery Centre (DISC), located at the heart of the Cambridge Biomedical Campus, is designed to play a central role in our mission to deliver life-changing medicines to patients. As our largest research and development centre in the UK, it will have more than 2,000 people working across therapy areas and drug discovery and development once fully occupied.

Find out more about our Cambridge campus and the DISC, here: https://www.astrazeneca.com/our-company/our-locations/cambridge.html

What you will do:

  • Develop potency and characterisation bioassays based on drug mode of action with a focus on RNA and RNA – lipid nanoparticle (LNP) products (e.g., mRNAs) using techniques like cell transfection followed by immunoassays to quantify levels and examine functionality of the transgene protein products

  • Enable transfer of any developed methods to other groups as appropriate

  • Carry out routine sample testing to feed into product development CMC activities

  • Convert opportunities and resources to succeed and thrive around the team and communicate achievements to different audiences, including at team meetings, global group meetings and in matrix teams

  • Learn from experience and guidelines/documentation to increase responsibilities and complexity of tasks to be performed with a higher level of autonomy

Essential:

  • Minimum BSc (or equivalent) in Cell Biology, Virology, Immunology, Cellular Biochemistry, or related field together with relevant professional/academic experience

  • Familiarity and extensive hands-on experience with mammalian cell culture and in-depth experience with immunoassay techniques, e.g., ELISA, DELFIA, HTRF

  • Optimisation of experimental protocols for biological assays (e.g., cell-based immunoassays) to control quality of results supporting drug development decisions

  • Good time management skills, ability to flex and handle multiple responsibilities and tasks on a regular basis

Desired:

  • Comprehensive experience in cellular delivery of RNAs and RNA:LNPs

  • Small scale RNA synthesis (IVT), LNP formulation and basic RNA analytics

  • Drug development experience in Pharma/Biotech industry

  • Scientific background in virology, immunology or vaccines

Why AstraZeneca!

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial -finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering ground-breaking methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what’s next!

Are you already imagining yourself joining our team, because we can’t wait to hear from you.

Where can I find out more

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook - https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram - https://www.instagram.com/astrazeneca_careers/?hl=en

Job Posted: 09/08/2023

Bioassay Development Scientist
AstraZeneca

www.astrazeneca.com
Cambridge, United Kingdom
Pascal Soriot
$10+ billion (USD)
10000+ Employees
Company - Public
Biotech & Pharmaceuticals
1913
Related Jobs

All Related Listed jobs

Store Manager
David's Bridal London, England 22708 - 32750 GBP ANNUAL Today

While performing the duties of this job, the employee is required to stand, walk, and sit for extended periods of time; reach for tools and objects with hands

Technical Business Analyst
North Yorkshire County Council Northallerton, England 38296 - 42503 GBP ANNUAL Today

A variety of benefits are available such as generous annual leave entitlement, flexible working, excellent pension scheme, salary sacrifice car, cycle,

housekeeper
Fish Window Cleaning Beaverton, OR 60000 - 40000 USD ANNUAL Today
Cyber Consultant
Datasource Southampton, England 60000 - 70000 GBP ANNUAL Today

My client is looking for a Cyber Engineer to provide support for external customers cyber and engineering solutions. Flexi Leave and Flexi Time Scheme.

Private Dentist
mydentist Newport, Newport, Wales 33851 - 75593 GBP ANNUAL Today

Well-led practice with a friendly and supportive team, including fully-qualified and experienced dental nurses. Paid parking on Pyle Street.