Associate Scientist – Molecular Biology Oxford, England
Job description
T-Cypher Bio
Associate Scientist – Molecular Biology
T-Cypher Bio is an early-stage, innovative biotechnology company aiming to unlock an expansive target space to build a pipeline of novel, T-cell receptor (TCR)-based therapeutics.
What you will do
We are seeking a highly motivated Molecular Biologist to join our team. The successful candidate will be responsible for conducting experiments related to building our TCR-therapeutic pipeline. The ideal candidate should have a solid understanding of molecular biology techniques, hands-on experience executing experiments, and be familiar with standard molecular biology software and databases.
Key Responsibilities
- Design and execute molecular biology experiments, including DNA/RNA isolation, cloning, PCR, qPCR, gel electrophoresis, and next-generation sequencing
- Design and delivery of expression constructs to cells
- Engineering of cell lines for platform development
- Participate in group and project meetings, offering insights and expertise on technical elements to advance research projects
- Analyse and record experimental results and communicate findings to the team and to management
- Maintain and implement good laboratory practices, including accurate laboratory notebook systems, instrument and reagent maintenance, and personnel safety precautions
To be successful you will need
- BSc in molecular biology, biochemistry, molecular immunology, or a related discipline with relevant experience within industry or academia post BSc.
- Experience with a wide range of molecular biology techniques, such as PCR, qPCR, restriction digests, ligations, assembly methods (e.g. Gibson), mRNA production, and agarose gel electrophoresis
- Experience with DNA sequence analysis and construct design using in silico software tools (e.g. Snapgene)
- Experience with DNA extraction methods, including mini, midi and maxiprep scale
- Experience culturing E coli
- Experience with genome editing technologies such as CRISPR-based methods, base-editing, deletions, knock-ins and gene silencing is desirable.
- Familiarity with preparation of samples for Next Generation sequencing methods e.g. Illumina MiSeq
- Desire to own and lead research projects whilst functioning as part of a wider research team
- Ability to adapt to multiple roles in an evolving company
- Enjoy working towards challenging goals in a fast-moving environment
- Ability to follow and write protocols and SOPs
- Knowledge of health and safety regulations in a laboratory environment
- Strong organizational and communication skills (both written and verbal)
Desirable:
- Experience in cell therapy
- Experience working with peptide:HLA molecules
- T cell and Immunology knowledge
- Experience in Next generation sequencing
What we offer
Competitive salary and benefits commensurate with qualifications and experience.
Modern, well-equipped office and laboratory facilities on Oxford Science Park.
Training and development opportunities in-line with the company’s goals and growth plans.
An exciting opportunity to help establish an early-stage biotech with ambitions to impact patients’ lives.
How to apply
Please submit your CV and a cover letter through this posting.
Applications will be evaluated in the order that they are received.
You are encouraged to apply as soon as possible.
Applications will close once the position is filled.
