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Interested in a career in Life Sciences? Based on the Cambridge Research Park (near Waterbeach), Horizon is part of the Perkin Elmer family. Our mission is to accelerate the speed of life-saving medicines to the market by providing researchers in the pharma & biotech community with worldclass cell-based assay and cell line engineering research services that are dedicated to understanding and interrogating the biology behind genomics, oncology, and the immune system.

With Innovative Thinking, We Are Changing Things For The Better. Our dedicated team of employees worldwide is passionate about helping customers work to create healthier families, improve the quality of life, and sustain the well-being and longevity of people globally.

As a Scientist 2 in the Cell Line Development group, you will be responsible for executing cell and molecular biology workflows to produce genetically modified mammalian cell lines for customers to use in their drug discovery efforts. Our teams work in a manufacturing-style format using modular workflows to maximise throughput, efficiency, and on-time delivery. You will have the opportunity to use CRISPR-Cas9 and other gene modulation technologies, laboratory automation and information management systems and work in a collaborative, inclusive, team environment.

This is a lab-based role with a strong focus on maximising day-to-day efficiency within defined quality standards, processes, and timelines. Candidates should be organised, self-motivated, pro-active, solution finders, who are flexible in their approach and thrive in a dynamic environment, working to tight timelines.

Note that this position WILL REQUIRE flexible working on a rota basis, to cover 7-day operations (e.g. iPSC work).

Key Responsibilities

With a quality mindset, contribute to the execution of mammalian cell line development projects. In your daily activities you will:

• Use various cell and molecular biology techniques, laboratory automation and lab information management systems (LIMS) to ensure projects move forward within the expected timelines and specifications
• Analyse and interpret the results of such activities; identify and solve problems
• Use internal and external knowledge to identify process improvement opportunities and implement new ways of working that have a direct impact on productivity and/or quality
• In areas where you are a subject matter expert, contribute to training material and Standard Operating Procedures (SOPs) to disseminate knowledge and skills
• Communicate data and information clearly to your colleagues
• Use resources effectively, holding yourself and others accountable for high standards
• Be a champion in operational delivery and help direct day-to-day laboratory activities and report on milestones delivery

You will also be required to work collaboratively and be an effective team member within our overall Cell-based Services Department, supporting your own and other groups, as appropriate

Essential Competencies & Requirements

• Highly experienced in mammalian cell culture, excellent aseptic technique and experience performing various cell based assays, for example growth, fluorescent, luminescent and imaging assays, FACS, transfections and/or lentiviral techniques etc.
• Working knowledge of molecular biology techniques, particularly in the context of PCR and genotyping
• Understanding of Quality and what a Production environment is in the context of the biotechnology/pharmaceutical industry
• A strong interest in using laboratory automation and information management systems to produce high quality products
• Self-aware with a diligent nature, good attention to detail and good record keeping skills
• Excellent organisational ability to plan and prioritise work
• Excellent interpersonal and communication skills
• Experience of performing in a busy team environment, working collaboratively to achieve shared goals and objectives

Desirable Competencies & Requirements

• Practical experience with liquid handling robotic equipment and/or information management systems (LIMS) (although full training will be provided)
• Practical experience of molecular biology techniques such as PCR, gel electrophoresis, interpretation of sequencing data, design strategies etc
• Experience with more complex cellular models such as iPSC, primary cells etc
• Experience in applying in Lean methodologies (e.g. 5S, 8-wastes, Kaizen etc)