Research Scientist, Biologics Engineering, Oncology R&D Cambridge, East of England, England
Job description
We are looking for a highly motivated Research Scientist to join our Biologics Engineering team in Cambridge, UK. As a Research Scientist, you will be a key member of a team passionate about developing the next generation of Immuno-Oncological biologics and Immune Cell Engagers. You will bring your knowledge and practical experience in Biologics expression and purification to develop the next generation of drug candidates.
About AstraZeneca
At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.
Site description
Granta Park, Cambridge (UK), is one of over 400 sites here at AstraZeneca, providing an environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities. It’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you…Cambridge is one of the bioscience hotspots in the world and plays a central role in our mission to deliver life-changing medicines to patients. Granta Park has a gym, nursery, and central restaurant/coffee place as part of the science park facilities that are accessible to our staff. We also have our own bistro and deli in the AZ buildings. There are regular lunch & learn events including running clubs and after work socials. This is our biggest and most spacious lab site with easy access from all major routes and ample car parking available - come and join us! Please be aware that towards the end of 2023 you will be required to move to our new state of the art Cambridge Biomedical Centre.
Business Unit
In the Oncology Business Unit, we relentlessly follow the science, challenging the status quo to deliver more effective treatments to patients in need. Our dedication means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease. The Biologics Engineering team is responsible for the discovery and optimisation of biological candidate drugs to support all therapy area drug discovery pipelines and for the development of in-house biologics discovery platforms and novel drug modalities to support future drug discovery efforts. Fast-paced, it takes agility and responsiveness to stay committed in our pursuit of excellence.
What you'll do
Contribute to running lab processes for expressing and analysing Next Generation Biologics, such as multi-specific mAbs
Provide hands-on for recombinant protein expression, purification and characterisation of the protein produced
Provide recommendations and support to design, construct and purify plasmids
Analyse experimental data, make details observations and interpretations to support project strategy
Keep an accurate record of data and experimental results
Participates to internal meetings and actively engage with project stakeholders, and team members
Essential skills
Level 4/5 qualification e.g. NVQ, apprenticeship or Bachelor/Master of Science degree in life sciences
Knowledge and understanding of standard cloning techniques and molecular biology (e.g. PCR, plasmid purification, DNA sequencing, primer design)
Knowledge and experience of recombinant protein expression (e.g. mammalian, e. coli) and purification (e.g. AKTA systems, SDS-PAGE)
Ability to conduct and interpret experiments with a track record in protein sciences or protein engineering
Attention to detail and good time management
Desirable skills
Experience in producing and analysing Antibodies
Experience in multiple cloning approaches (Golden gate, Gibson Assembly)
Experience with mammalian expression system (e.g. CHO-K1, HEK293)
Competitive salary & benefits
Close date: 16/05/2023
Why AstraZeneca?
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be.
So, what’s next!
Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available, and we hope it’s yours.
Where can I find out more?
Our Social Media,
Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/
Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/
Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en
