research scientist Macclesfield, England
Job description
Role Crystallisation Scientist
Location Alderley Park, Cheshire, England
Job Type Permanent
Salary £30,000 - £50,000
Date posted 5th April 2023
Start date ASAP
The Company
Sai Life Sciences is a leading global Contract Research & Development and Manufacturing Organisation (CDMO) that provides integrated drug substance services to the biotechnology and pharmaceutical industries. With recently expanded process development labs in Manchester, UK & Hyderabad, India, and increased commercial manufacturing capacity in Bidar, India, Sai is working with 7 of the top 10 pharma companies globally, as well as many leading smaller biotechs. We work with our clients to accelerate the discovery, development and manufacture of complex small molecules for a healthier tomorrow. With more than 2500 staff globally andambitious growth plans, our vision is to support our global innovator partners to bring 25 new medicines to life by 2025.
Marking the completion of 20 years since inception in 2019, the company began an organisation-wide initiative to significantly expand and upgrade its R&D and manufacturing facilities, deepen scientific & technological capabilities, strengthen automation and data systems, and above all raise the bar for safety, quality and customer focus. Guided by the insights and feedback from its customers, it committed to investing over US$150M between 2019 and 2023. Part of this investment in 2020 were the new state of the art laboratories in our centre of excellence for process chemistry and analytical development at the Alderley Park Science Park, situated on the outskirts of Manchester, where we are now looking to expand our team. Our overall team currently consists of >60 multi-disciplinary scientists (chemists, analysts and engineers).
Non-GMP manufacture of kg quantities of intermediates and APIs is currently possible within our bespoke Scaleup laboratory facility. During Q4 2022 a new GMP Kilo-lab facility will be created which is capable of kg quantities of GMP API suitable for early phase clinical studies. The developed processes may then be transferred to Sai’s manufacturing sites in India for further scale-up as required.
This is a great opportunity to work with an expanding global organisation and work closely with some of the most innovative biotech and pharma companies on their most important programmes.
The role will be based in Alderley Park, Cheshire, UK and will require right to work in the UK. Occasional travel, domestic and international to India may be required.
The Role
You will join a team that identifies, develops and optimises synthetic routes to APIs, supporting both early and late phase development.
The successful candidate will have a strong technical grounding in crystallisation design and control of physical properties, ideally with at least 2 years’ experience in a relevant industry. Candidates fresh from academia will also be considered provided they have relevant research experience.
The role requires a detailed knowledge of the fundamental science and particle properties underpinning particle formation, particle growth, product isolation and drying.
For those more experienced candidates, you will have demonstrated expertise in the successful transfer of processes developed in the laboratory to pilot and/or manufacturing scale as part of a team responsible for developing robust, high yielding processes that control quality and are readily scaled up.
You will be responsible for delivery of phase appropriate particle formation, isolation and drying processes for relevant projects at Manchester.
You will deliver projects at all phases of development as part of an interdisciplinary team of scientists and engineers applying particle science and particle engineering concepts in tandem with the application of cutting-edge screening, scale-up and PAT technology.
Essential Requirements
BSc, MSc, PhD or Post-doctoral research project with a specialism in Particle Sciences or Crystallisation or a related discipline.
Expertise in the application of available techniques to assess the physical properties of materials and their potential effects on chemical processes.
Key Roles and Responsibilities
Providing input to design, optimise and troubleshoot crystallisation, isolation and drying processes to deliver robust and reliable processes for pilot scale and manufacturing plant.
Working within multi-functional project teams operating to tight deadlines.
Executing work to meet project timelines.
Application of new or novel technologies to support projects.
Key Attributes
Ability to solve complex scientific problems.
Excellent communication skills to interact internally with project teams and externally with customers
Collaboration and influencing skills to build partnerships with the other disciplines at Manchester, similar groups at our R&T centre in Hyderabad, and with our customers.
Conscientious with a can-do attitude and thorough attention to detail.
A team player.
The Offer
A competitive Salary and Benefits package including company pension, health and life insurance, 25 days holiday per year and enhanced family leave.
Work in a state-of-the-art facility on one of the country's leading Biotech & Life Science Parks.
Flexible working hours and conditions to suit the right candidate.
Next steps
Please send your CV and cover letter to [email protected] with details of the role that you are applying for.
As an Equal Opportunities employer, we welcome applications from all suitably qualified persons regardless of their race, sex, disability, religion/belief, sexual orientation or age.
Job Types: Full-time, Permanent
Salary: £30,000.00-£60,000.00 per year
Benefits:
- Casual dress
- Company pension
- Employee discount
- Flexitime
- Life insurance
- On-site parking
- Private medical insurance
- Referral programme
- Sick pay
- Store discount
Schedule:
- Flexitime
- Monday to Friday
- No weekends
Application question(s):
- Please advise of current notice period in weeks
- Please advise of notice period in weeks.
Education:
- Bachelor's (required)
Work authorisation:
- United Kingdom (preferred)
Work Location: In person
