research scientist Tarrytown, NY
Job description
JOB DESCRIPTION
The Viral Delivery Technologies group is seeking an independent and highly motivated scientist to support the development of novel gene therapy viral platform. This role involves conducting research activities around the design, characterization, and validation of novel Adeno-associated virus vectors in vitro and in vivo. You will work closely with therapeutic groups to expand upon our antibody-retargeted viral vector platform for gene therapy applications by developing the efficacy and tissue specificity of vectors.
As a Sr. Assoc Scientist, a typical day might include:
Design, execute, analyze, and troubleshoot in vitro and in vivo experiments to characterize and validate new antibody target receptors and viral vector constructs.
Execute and optimize rAAV production protocols for further developing our understanding of AAV biology to inform novel vector development
Run cell-based assays to characterize the infectivity efficacy and specificity of novel AAV vectors.
Perform basic molecular biology techniques (Cloning, Western blotting, DNA/RNA extractions, PCR, RT-PCR, quantitative PCR, etc.), biochemical/immunological assays (ELISA, flow cytometry).
Work closely with therapeutic groups to identify targets, design in vivo experiments, evaluate vector biodistribution, and develop therapeutic applications of retargeted viral vectors.
Evaluate candidate antibodies to target tissues of cell types of interest for viral gene delivery.
Coordinate with CROs to evaluate candidate viral vectors in non-human primate models.
Participate in team meetings and preparation of regular presentations for departmental meetings.
This role may be for you if you:
Enjoy working in an innovation driven, highly collaborative and fast paced environment.
Can effectively balance multiple projects independently across multiple subjects.
Have excellent communication skills and strong work ethics
Have keen attention to detail.
This position requires at minima a Master’s degree or Bachelor's degree with 2 years’ experience in Molecular Biology, Biochemistry, cell biology, Virology or related field. Qualified applicants should have relevant experience in molecular biology techniques, mammalian cell culture, manipulation and purification of viruses or proteins, development of cell-based assays for detection of reporter proteins, and use of antibodies for various applications. Previous experience with AAV production and manipulation, in vivo delivery and characterization of viral vectors, as well as familiarity with key antibody properties will constitute distinct advantages. Level will be commensurate with experience
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Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.
The salary ranges provided are shown in accordance with U.S. law and apply to U.S. based positions, where the hired candidate will be located in the U.S. If you are outside the U.S, please speak with your recruiter about salaries and benefits in your location.
Salary Range (annually)
