Genomic Expert

We are seeking a highly motivated scientist with experience in genomic analysis, bioinformatics and computational biology to join the Digital Biology Twin (DTB) laboratory in GSK. DBT has been newly set up to help clinical development for further drug pipelines and to contribute to preclinical development programmes within GSK. The successful candidate will work as part of a team that, by exploiting patient-derived organoids, is developing and implementing cutting-edge cellular, genomic and molecular techniques with a multimodality analytic approach, plus machine learning models which are coupled with paired patient-derived data feedback, to provide mechanistic markers/novel pharmacodynamic readout, improve cancer patient risk stratification as well as to predict future targeted and/or immuno-therapy susceptibilities.

The DBT lab is part of a new Unit (DBT) which has existing functional and strategic linkages with the other units on common Oncology related projects e.g. AI/ML, EMU, Genomic Science (GS), Clinical Imaging (CPEM) and Bio-imaging (IVIVT).

Join our challenge to get ahead of disease together!

In this role, you will also ensure synergy and collaboration between this new unit and KCL scientists within the GSK-King’s College London (KCL) Translational Oncology Research Hub (https://www.theguardian.com/business/2021/sep/17/gsk-teams-with-kings-college-to-use-ai-to-fight-cancer), an exclusive research collaboration between GSK and the Comprehensive Cancer Centre at KCL.

In addition, you will interact with experts in other subject areas e.g. AI/ML, EMU, Development (e.g. Oncology team EDL & MDL), various Oncology-relevant Research Units (RU), functional genomics (FxG), proteomics, Clinical Imaging, etc., working together towards improving patient stratification of clinical treatments using GSK assets, alone or in combination with standard of care treatment.

In this role you will

• Spatial omics analysis (e.g. CosMx)
• Data acquisition and elaboration from RNAseq and whole genome sequencing analysis
• Building and maintaining bioinformatics pipelines
• Deriving information from NGS data
• Collecting and reporting data to the lab head.
• Interacting with the other team member to facilitate the development and optimisation of the analysis
• Solving technical issues operate as part of a cross-functional project team

Why you?

Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

• BSc or MSc in Bioinformatics, Computational Biology or related

• Extensive experience in analysis of major next-generation sequencing techniques and generation of insights from such data
• 3 years+ Python programming experience
• Experience using High Performance Computing Environments
• Strong statistical skills
• Experience in Oxford Nanopore data analysis
• Experience in collaboration with biopharma

Preferred Qualifications & Skills:

If you have the following characteristics, it would be a plus:

• PhD in Bioinformatics, Computational Biology or related
• Experience with Linux, Singularity and Docker
• Experience with building pipelines in Nextflow
• Biological expertise in genomic material collection

Closing Date for Applications: Tuesday 4th July 2023 (COB)

Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

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#LI-GSK

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to positively impact the health of 2.5 billion people by the end of 2030.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We’re committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

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