CPMS Immuno-inflammation

We have an exciting opportunity at GlaxoSmithKline (GSK) for a highly motivated Quantitative Clinical Pharmacologist to join our UK team as part of the global department of Clinical Pharmacology Modeling & Simulation.

This is an excellent role to use quantitative clinical pharmacology to accelerate the delivery of new medicines to patients by enhancing drug program efficiency and business decision quality. The work directly supports our mission to help our patients do more, feel better and live longer.

The job level will depend on the skills and achievements of the successful candidate. At GSK, we develop therapies of various modalities for a broad range of indications. As a member of a global department with diverse expertise, you will enjoy a highly supportive environment for scientific innovation, business impact and professional growth.

Key responsibilities:

• Develop model informed clinical pharmacology strategies and integrate into overall project and clinical development plans
• CPMS representative on matrix (multidisciplinary) teams present strategy and discuss outcome of model-based approaches via interactions with internal governance boards and regulatory agencies.
• Plan, execute and report appropriate pharmacometrics analysis (e.g. translational drug-disease modeling, population PK, exposure-response analysis, simulation-based trial design).
• Contribute to clinical program design, trial protocols, analysis plans, study reports and regulatory submissions.
• Apply innovative techniques such as longitudinal exposure-response analysis, model-based meta-analysis and item-response analysis to improve data use and trial efficiency.
• Promote model-informed drug discovery and development through external collaboration, journal publication and conference presentation.

About You

Basic Qualifications:

• A doctorate relevant to Quantitative Clinical Pharmacology, and experience in using modeling/simulation to solve practical problems in industry or academia.
• Proven skills in pharmacokinetic-pharmacodynamic and longitudinal disease modeling; and verifiable proficiency in pharmacometrics tools NONMEM, Monolix, R or SAS
• Thorough understanding and ability to apply appropriate regulatory and ICH guidelines relevant for clinical pharmacology strategy supporting end to end drug development
• Strong drive and learning agility to build knowledge on a drug-disease system, symptom progression, standard of care, and trial design and endpoints
• Demonstrated aptitude for productive collaboration in a multi-discipline team, using effective communication and taking personal accountability for timely delivery of results
• Clear evidence of ability to make sound judgement in complex situations and adapt to changing business needs by prioritising multiple tasks

Why GSK?

At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader in Consumer Health, strengthening our leadership, and transforming our commercial execution. Now, we’re making the biggest changes we’ve made to our business in over 20 years. We’re on track to separate and create two new companies in 2022: New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and genetics science; and a new world-leading consumer healthcare company of loved and trusted brands.

With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of disease together – all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; and as a new GSK where outstanding people thrive.

Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culture that is ambitious for patients – so we deliver what matters better and faster; accountable for impact – with clear ownership of goals and support to succeed; and where we do the right thing. So, if you’re ready to improve the lives of billions, join us at this exciting moment in our journey. Join our challenge to get Ahead Together.

#LI-GSK

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to positively impact the health of 2.5 billion people by the end of 2030.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We’re committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

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