Biotransformation Senior Scientist, DMPK

Do you feel passionate about the possibilities of science to change lives? Do you have a background in analytical science / chemistry and a drive to deliver data that directly impacts drug discovery and development projects? If so, this may be the role for you. We currently have an exciting opportunity for a highly motivated analytical scientist to join our biotransformation team.

AstraZeneca

AstraZeneca is a global biopharmaceutical company driven by what science can do. We are dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions that enrich the lives of patients. Our vision is to be at the forefront of developing the new generation of cancer therapies.

Oncology R&D DMPK department

The Oncology Drug Metabolism and Pharmacokinetics (DMPK) department provides ADME/PK, as well as translational PK/PD Modelling & Simulation support to all modalities in our discovery and development portfolio.

Be part of fulfilling our ambition to be world leaders in Oncology. Oncology R&D is a major focus area and growth platform at AstraZeneca, and there are countless new indications and targets in our pipeline. By leveraging our commercialised portfolio, we are confident we can change the practice of medicine and redefine cancer treatment. We’re brave disruptors – entrepreneurial, courageous, and pioneering in our approach. Here you can step up, take personal accountability, and lead changes in our ever-evolving environment.

What you’ll do

You will join a global biotransformation team that provides scientific leadership and supports our diverse portfolio including small molecules, PROTACs, antibody drugs conjugates (ADCs) and nanomedicines. The qualified candidate will work alongside with our DMPK team in Boston (US), maintaining close collaboration within the global department. The position is based in Cambridge UK.

Accountabilities

• Delivering biotransformation studies to assess metabolic pathways of molecules including weak-spot identification, structural elucidation of metabolites and assessment of bioactivation.

• Delivering in vitro/in vivo biotransformation studies to support drug candidate selection and regulatory submissions.

• Participating in validating cutting-edge analytical methodologies to support this core function.

• Authoring technical reports, peer-reviewed publications, and oral presentations.

Minimum Requirements – Education, Experience and Capabilities

• first degree in Analytical Chemistry/Biochemistry/Biology/Pharmacology ideally followed by PhD or experience as biotransformation / Met-ID / analytical scientist.

Extensive experience and expertise in several of the following:

• Structural elucidation through the generation and interpretation of high resolution mass spectra and UV spectra and being a speaking partner to the NMR specialists.

• Experience of working with Thermo scientific FT orbitrap mass spectrometers (Q-Exactive, Orbitrap Fusion) would be advantageous.

• LC-MS method development and problem solving

• Understanding of drug metabolism and how this may affect structural compound design and risk assessment for drug candidates is desirable but not essential

• Ability to design and ideally conduct in-vitro experiments for metabolite identification studies (Met-ID) is desirable, but training will also be provided for the suitable candidate.

• Excellent interpersonal skills that lead to successful collaborative work-relationships

Location: Cambridge,UK

Cambridge Site location

Welcome to Cambridge, one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you…

Where life meets Science…Chesterford Research Park offers advanced laboratory and office space set within 250 acres of idyllic parkland near Cambridge – modern, dynamic, flexible facilities perfectly appointed for biotechnology, pharmaceutical and R&D companies. You will have access to a stylish, fully air conditioned health and fitness centre, an onsite restaurant, Lunch & Learn development activities, all within a spacious environment while utilising the most advanced technology.

This role will then relocate to the Cambridge Biomedical Campus, when the site is completed - this site combines world-class biomedical research, patient care and education on a single site location in the heart of Cambridge.

Competitive salary and benefits package on offer.

The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, A performance recognition scheme and a competitive, generous remuneration package.

Why AstraZeneca?

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

If you are already imagining yourself joining our team. Good, because we can’t wait to hear from you!

Where can I find out more?

Reach out to connect with our recruiter - Sophie Halpin - via LinkedIn on:

https://www.linkedin.com/in/sophie-beverley-halpin/ for a confidential discussion to explore how this role could be your next career move

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