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We have an exciting opportunity for two Biochemists to join our GSK Enzyme Engineering and Biocatalysis group based in Stevenage, UK.

As a biochemist, you will be responsible for supporting our work developing new enzymes for the production and modification of nucleic acid products with applications across the full GSK portfolio. Working closely with project teams, you would develop assays for understanding and improving enzymes of interest, identify novel enzymes for the synthesis of complex oligonucleotide products, and help support enzyme evolution programs as part of an interdisciplinary team of experts.

The role is fast-paced and dynamic, you will thrive in this environment if you are able to effectively manage multiple priorities, communicate your recommendations clearly and enjoy working in teams.

In this role you will

• Be responsible for a wide range of activities supporting our directed evolution workflow on a variety of protein engineering activities.
• Identify new ligase, and other nucleotide and XNA engaging enzyme variants to support our portfolio
• Develop appropriate assays for nucleic acid molecules to screen and identify improved enzyme variants in high throughput
• Understand enzyme mechanistic details of reaction kinetics
• Design experiments, collecting and analysing data using programs such as MS Excel, TIBCO Spotfire and bespoke software tools to inform decisions
• Support scale up activities for generation and use of enzymes
• Interact with partners in discovery, development, and manufacturing to identify and pursue enzyme opportunities
• Generate conclusion reports, present data in team meetings & participate in writing of abstracts & publications
• Conduct scientific work programs and make contributions both independently and as a member of a team with other R&D staff
• Maintain customer focus, motivating self, and demonstrating a high degree of urgency
• Exhibit flexibility, being open to new ways of working

Why you?

Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

• Bachelor’s degree (or equivalent) in a relevant life sciences or chemistry course
• Practical laboratory experience of the identification of enzymes to perform reactions of interest, and the optimization of those enzymes under synthetically relevant conditions

Preferred Qualifications & Skills:

If you have the following characteristics, it would be a plus:

• Practical laboratory experience with nucleic acid-modifying enzymes such as ligases, polymerases, oligonucleotide synthetic enzymes, phosphatases, kinases,
• Familiarity with lab automation equipment and its use in high throughput experimentation with recombinant enzymes
• Experience with high throughput assay development, Design of Experiments, etc.
• Demonstrated ability to work in multi-disciplinary teams, displaying excellent interpersonal, organizational, and communication skills
• Ability to analyse and visualize large multidimensional datasets
• Demonstrated excellence in the end-to-end execution of directed evolution projects including enzyme identification, library design, generation, and screening

Closing Date for Applications: 23rd April 2023 (COB)

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

R&D

We’re combining the power of genetic and genomic insights into what causes disease, with the speed and scale of artificial intelligence and machine learning (AI/ML) to make better predictions about who a treatment might work for, and why. We believe this powerful combination of data and technology holds the key to fundamentally transforming medical discovery for the better, improving R&D success rates and shaping how even the most challenging diseases, like neurological conditions and cancer, can be both prevented and treated.

In 2021 we delivered four major product approvals: Cabenuva for HIV, Jemperli for endometrial cancer, Xevudy for COVID-19 and Apretude, our new long-acting medicine for HIV prevention:

Find out more:

Our approach to R&D

#CMCDevelopmentGSK

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.

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We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on [email protected] or 0808 234 4391. Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels

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